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Product Description
Hot Anesthetics Raw Material Phenacetin/Phenacet with Safetest Delivery Acetophenetidin
Phenacetin Local Anesthetics Pharmaceutical Material
Phenacetin was widely used until the third quarter of the twentieth century, often in the form of an "A.P.C." or aspirin-phe-nacetin-caffeine compound analgesic, as a remedy for fever and pain. An early formulation (1919) was Vincent's APC in Australia. However the U.S. Food and Drug Administration ordered the withdrawal of drugs containing phe-nacetin in November 1983, owing to its carcinogenic and kidney-damaging properties (Federal Register of October 5, 1983 (48 FR 45466)). It was also banned in India.As a result some branded, previously phe-nacetin-based preparations continued to be sold, but with the phe-nacetin replaced by safer alternatives. A popular brand of phe-nacetin was Roche's Saridon, which was reformulated in 1983 to contain propyphenazone, paracetamol and caffeine. Coricidin was also reformulated without phe-nacetin. Paracetamol is a metabolite of phe-nacetin with similar analgesic and antipyretic effects, but the new formulation has not been found to have phe-nacetin's carcinogenicity.
Phenacetin is now being used as a cutting agent to adulterate in the UK and Canada, owing to the similar physical features of the two drugs.
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