Goserelin Acetate CAS 145781-92-6

Goserelin Acetate CAS 145781-92-6

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WuMeitech
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China
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Product Description

Goserelin Acetate CAS 145781-92-6
Specifications
Top Quality Peptide Raw Goserelin Acetate 145781-92-6

Basic Info
Suitable for: Adult
Purity: >99%
Delivery Time: Within 12 Hours After Receiving Your Payment
Shelf Life: Two Years
Trademark: WuMeiTech
Specification: 100% Qualified
Top Quality Peptide Raw Goserelin Acetate 145781-92-6



Product Description

Goserelin Acetate
Sequence: Pyr-His-Trp-Ser-Tyr-D-Ser(tBu)-Leu-Arg-Pro-Aza-Gly-NH2
Cas No.: 145781-92-6
Molecular Formula: C61H88N18O16
Molecular Weight: 1269.4
Purity (HPLC): 98.0%min.
Appearance: White powder
Single Impurity (HPLC): 0.5%max
Amino Acid Composition: ±10% of theoretical
Peptide Content (N%): ?80.0%
Water Content(Karl Fischer): ?8.0%
Acetate Content(HPIC): ?10.0%
MS (ESI): Consistent
Mass Balance: 95.0~105.0%

Product Description:

Goserelin is a synthetic analogue of a naturally occurring luteinizing-hormone releasing hormone (LHRH). Bioavailability is almost complete. Goserelin is poorly protein bound and has a serum elimination half-life of two to four hours in patients with normal renal function. The half-life increases with patients with impaired renal function. There is no significant change in pharmacokinetics in subjects with liver failure. After administration, peak serum concentrations are reached in about two hours. It rapidly binds to the LHRH receptor cells in the pituitary gland thus leading to an initial increase in production of luteinizing hormone and thus leading to an initial increase in the production of corresponding sex hormones. This initial flare may be treated by co-prescribing/co-administering an androgen receptor antagonist such as bicalutamide (Casodex). Eventually, after a period of about 14-21 days, production of LH is greatly reduced due to receptor downregulation, and sex hormones are generally reduced to castrate levels

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