Factory Supply 99% High Purity Powder Sitagliptin CAS 486460-32-6

Factory Supply 99% High Purity Powder Sitagliptin CAS 486460-32-6

Brand:
Hanhong
Place of origin:
China
Model Number:
486460-32-6
Dimension:
0.00 X 0.00 X 0.00 cm
SKU:
486460-32-6
Certification:
ISO 9000/9001/9004/19011: 2000
Minimum Orders:
1kg
Available:
2
Price:
$20
 
 
Ship To (shipping cost):
Canada ($10), United States ($10)
Packing:
bags
Delivery Time:
7-15 days
Payments:
Payments
Guarantee:
Get the item you ordered or get your money back.

Seller Details

Rating:

positive ratings
Location:
China
Joined:
20 March 2023
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Product Description

CAS No.486460-32-6 Chemical Name:Sitagliptin SynonymsSitagliptin base;(3R)-3-Amino-1-[3-(trifluoromethyl)-5,6,7,8-tetrahydro-1,2,4-triazolo[4,3-a]pyrazin-7-yl]-4-(2,4,5-trifluorophenyl)butan-1-one;(R)-3-amino-1-(3-(trifluoromethyl)-5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)-4-(2,4,5-trifluorophenyl)butan-1-one;Janumet;Sitagliptin free base;Sitagliptin API;Sitagliptin-D4;Unii-qfp0p1dv7z;1,2,4-Triazolo(4,3-A)pyrazine, 7-((3R)-3-amino-1-oxo-4-(2,4,5-trifluorophenyl)butyl)-5,6,7,8-tetrahydor-3-(trifluoromethyl)-;1-Butanone, 3-amino-1-[5,6-dihydro-3-(trifluoromethyl)-1,2,4-triazolo[4,3-a]pyrazin-7(8H)-yl]-4-(2,4,5-trifluorophenyl)-, (3R)- CBNumber:CB01449778 Molecular Formula:C16H15F6N5O Melting point 114.1-115.7 °C Boiling point 529.9±60.0 °C(Predicted) Density 1.61±0.1 g/cm3(Predicted) pka 7.20±0.10 Description Sitagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, is a first-in-class oral drug launched for the treatment of type 2 diabetes. It acts by slowing the inactivation of incretins, which are endogenous peptides involved in the physiologic regulation of glucose homeostasis. Incretin hormones, including glucagonlike peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP), are released by the intestine throughout the day, and levels are increased in response to a meal. When blood glucose concentrations are normal or elevated,GLP-1 and GIP increase the synthesis and release of insulin from pancreatic b cells via intracellular signaling pathways involving cAMP. GLP-1 also lowers glucagon secretion from pancreatic ?cells, which leads to reduced hepatic glucose production. Uses Sitagliptin is a useful pharmaceutical drug. Could be useful for treating intestinal inflammation, diabetes, pre-?diabetes, impaired glucose tolerance, hepatitis, and?/or inflammatory liver disease. Uses Labeled Sitagliptin , intended for use as an internal standard for the quantification of Sitagliptin by GC- or LC-mass spectrometry.

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