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Product Description
Dydrogesterone
Dydrogesterone CAS 152-62-5
Dydrogesterone EINECS:205-806-8
Dydrogesterone Molecular Formula:C21H28O2
Dydrogesterone Molecular Weight:312.45
Dydrogesterone Appearance:White or light yellow crystalline powder
Dydrogesterone , is also chemically known as 9?,10?-pregna-4,6-diene-3,20-dione.Dydrogesterone
Dydrogesterone has selective progestational activity and does not inhibit ovulation.[3] The greater rigidity of dydrogesterone also positively affects its selectivity,while natural progesterone is less selective, existing in different conformations that more easily bind to different receptors. As a consequence of its better bioavailability and the progestational activity of its main metabolites (20-, 21- and 16-hydroxy derivatives), the equivalent dose of dydrogesterone is 10-20 times lower than that of oral micronized progesterone.
The objective behind hormone replacement therapy is to actively increase the circulating levels of estrogen to control hot flushes and to prevent the long-term effects of the menopause, such as bone resorption and unfavourable changes in blood lipids. The administration of 17?-oestradiol halts, or reverses atrophic changes that occur due to the loss of endogenous oestradiol during the menopause.
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